Best Methylfolate Supplements in 2025 (Top 10: Codeage, Jarrow Formulas and More)
Discover the top-rated methylfolate supplements for improved mood, energy, and overall wellness. Find the right l-methylfolate for your needs.
Up to half of people carry common MTHFR variants. That means your body might not convert folic acid into the active folate it needs. Methylfolate delivers the bioactive form directly.
If you’ve felt foggy or tried folic acid with no change, methylfolate can help support mood, energy, and healthy methylation. Think of it as switching from regular gas to premium — sometimes the engine runs smoother. Keep it simple and start low if you’re new to active folate.
Contents
- The Best Methylfolate Supplements
- Thorne 5‑MTHF Active Methylfolate 1mg
- High-Potency L‑Methylfolate Plus B12
- Codeage Methylfolate B Complex 120 Caps
- Carlyle 15mg L‑Methylfolate Value Size
- NOW Foods Quatrefolic 1000 mcg Tablets
- Double Wood 1000 mcg Methylfolate Capsules
- Jarrow Formulas 400 mcg Methyl Folate
- Horbäch 1000 mcg Methyl Folate 200 Capsules
- Nutricost 1000 mcg Vegetarian Methylfolate
- One Elevated Double Strength Methylfolate Formula
- Final Thoughts on the Best Methylfolate Supplements
- What Is Methylfolate and What Is It For?
- Methylfolate vs. Folic Acid: What’s the Difference?
- How to Choose the Best Methylfolate Supplements
- Check Out the Best Methylfolate Supplements
- Also Check Out Other Helpful Articles
- Video About the Best Methylfolate Supplements
The Best Methylfolate Supplements
Thorne 5‑MTHF Active Methylfolate 1mg
A clinician‑preferred, evidence‑backed 1 mg 5‑MTHF that balances potency and safety for broad use. You get high manufacturing standards and a reputation for rigorous testing, which suits both everyday supplementation and practitioner recommendations.
Pros
- Respected, research-driven brand with high manufacturing standards
- Clinically relevant 1 mg 5‑MTHF dose for regular use
- Suitable for long-term daily maintenance and prenatal planning
Cons
- Lower per-capsule dose than therapeutic high‑dose products
- Higher price per pill compared with bulk budget brands
Why you might choose this one
This 5‑MTHF from a professional supplement company is formulated for consistent, reliable delivery of active folate. It’s a solid middle‑of‑the‑road dose — strong enough for meaningful effect but conservative compared with high‑potency therapeutic formulas. Because of Thorne’s manufacturing and clinical focus, many practitioners recommend it.
Notable features
- 1 mg (1000 mcg) of bioactive 5‑MTHF per serving
- Manufactured under strict quality controls and testing
- Designed to support methylation, cardiovascular health, and fetal development
If you want a product that professionals use and recommend, this offers peace of mind through consistent potency and purity.
Practical considerations
The 1 mg dose is comfortable for most people to start with and can be adjusted with clinician guidance. It’s a slightly more expensive option than some mass-market brands, but you pay for brand-driven quality controls and documented sourcing.
High-Potency L‑Methylfolate Plus B12
Provides a clinically high 15 mg dose of bioactive 5‑MTHF together with methylcobalamin, making it a strong option when you need robust methylation support. The formula is aimed at people who respond well to higher folate doses and want a combined B12 cofactor for synergy.
Pros
- Very high 15 mg 5‑MTHF dose for strong effect
- Includes methylcobalamin B12 to support methylation
- Good value relative to prescription pricing
Cons
- High dose may be excessive for some users
- Capsule size can be large for sensitive swallowers
What this formula is for
This formula gives you a pharmacologic-strength single ingredient focus: L‑methylfolate (5‑MTHF) at 15 mg plus methylcobalamin as the key cofactor. If you have MTHFR variants, chronic low folate signs, or a clinical plan from a practitioner that requires higher folate, this product fits that need. You should consult your clinician before starting such high doses.
Key features and practical benefits
- 15 mg L‑MTHF (5‑MTHF) per serving, which is much higher than typical OTC folate doses
- Methylcobalamin B12 included to support methylation and homocysteine metabolism
- Capsule format designed for daily use and longer-term supplementation
These features make it practical if you need powerful methylation support. Many users report improved energy and clearer thinking after consistent use; others start low and titrate up because of potency.
Limitations and usage tips
The strength is both the product's advantage and its main limitation: you may experience overstimulation, anxiety, or sleep disruption if you’re sensitive to methylated B vitamins. Start with a smaller fraction of the capsule or take every other day until you know how your body reacts. If you’re pregnant, breastfeeding, or taking prescription medications that affect folate or B12, check with your healthcare provider.
Codeage Methylfolate B Complex 120 Caps
Combines 5‑MTHF with methylcobalamin, riboflavin, betaine, and other B vitamins to support the methylation cycle comprehensively. It’s a convenient choice if you prefer a single capsule to cover multiple cofactors and nutrients.
Pros
- Comprehensive B complex with methylated vitamins
- Includes betaine and riboflavin for methylation support
- Two‑month supply at typical dosing
Cons
- More expensive than single‑ingredient folate options
- Multi‑ingredient formulas can complicate dose adjustments
Why pick a B complex approach
If you want more than folate alone, this blend gives you methylfolate plus methylcobalamin and additional B vitamins that participate directly in methylation pathways. That reduces the need to buy and combine separate supplements and makes daily adherence simpler.
Composition and practical benefits
- 5‑MTHF folate combined with methylated B12, riboflavin, betaine, and other B vitamins
- Aimed at supporting methylation, homocysteine metabolism, and overall B‑vitamin balance
- Packaged to provide approximately two months of supply at typical dosing
This makes the product ideal for someone who wants an all‑in‑one regimen to address methylation without complex stacking. Users often appreciate the convenience and report fewer prescription visits to sort out combinations.
Caveats and suggestions
Because it includes several active nutrients, adjustments are less granular than single‑nutrient options. If you need to fine‑tune folate or B12 independently, discuss with your clinician. Expect a higher price point, but weigh that against the convenience of one combined capsule.
Carlyle 15mg L‑Methylfolate Value Size
A high‑potency 15 mg L‑Methylfolate in a large 120‑capsule bottle designed to give you months of supply at a competitive price. It’s a practical choice if you’ve found benefit from higher methylfolate dosing and want to avoid frequent reorders.
Pros
- Large 120‑count bottle for long-term value
- 15 mg active L‑Methylfolate per capsule
- Non‑GMO and gluten‑free formulation
Cons
- Very high dose may not be appropriate for everyone
- Some users report no effect until dose is adjusted
Value-oriented high-potency option
This product pairs a therapeutic 15 mg dose of L‑Methylfolate with a value size bottle, which lowers per‑serving cost and reduces the need for frequent purchases. If you and your clinician have settled on a higher dose approach, this is built for long‑term use and convenience.
Key benefits and what to expect
- 15 mg L‑Methylfolate per capsule for robust methylation support
- 120 capsules per bottle for extended supply and lower cost per dose
- Free from common allergens and marketed as non‑GMO/gluten‑free
Users with MTHFR variants often choose larger supplies like this to maintain consistency. Many report improved mood stability and cognitive clarity with sustained use.
Limitations and guidance
Because of the potency, start low or split capsules until you determine your tolerance. If you’re combining this with other B supplements, monitor total folate and B12 intake to avoid overstimulation.
NOW Foods Quatrefolic 1000 mcg Tablets
Offers an accessible, bioavailable form of methylfolate (Quatrefolic) at 1,000 mcg per tablet with solid value for money. It’s a good entry point if you want effective folate support without a high price tag.
Pros
- Uses Quatrefolic form for reliable bioavailability
- Compact tablets that are easy to swallow
- Good value and widely available
Cons
- Not combined with methyl B12 or additional cofactors
- Some users prefer capsule formats or higher doses
Who this suits
This 1,000 mcg methylfolate uses Quatrefolic, a patented, well‑studied form that’s more bioavailable than folic acid. It’s ideal if you want effective active folate in a budget‑friendly, easy‑to‑use tablet that you can pair with other B vitamins if needed.
What you get
- 1,000 mcg methylfolate (Quatrefolic) per tablet
- Vegan, non‑GMO, and free from common allergens in many batches
- Compact tablet form that many people find easier to take
Many users find improved mood stability and energy when combined with a B12 source; if you need methylcobalamin specifically, you may add it separately.
Things to keep in mind
If you require a combined B‑complex or higher therapeutic doses, this single‑ingredient product may feel basic. It’s an efficient, economical building block for a tailored regimen but not an all‑in‑one methylation complex.
Double Wood 1000 mcg Methylfolate Capsules
A clean, 1,000 mcg methylfolate formula that emphasizes third‑party testing and ingredient transparency. It’s a reliable, straightforward product if you want verified purity and vegan‑friendly labeling.
Pros
- Third‑party testing increases confidence in purity
- Non‑GMO and vegan‑friendly formulation
- 120 capsules provide a long supply at a low price
Cons
- Single‑ingredient — no methylation cofactors included
- Some users may prefer a patented methylfolate form
Quality and transparency
This methylfolate capsule focuses on ingredient purity and testing. If you prioritize independent verification and vegan‑friendly credentials, you’ll appreciate the brand’s third‑party testing claims and clear labeling.
What the product offers
- 1,000 mcg methylfolate per capsule in a clean formulation
- 120 capsules per bottle for an extended supply
- Marketing highlights: third‑party testing, non‑GMO, vegan safe
The product is practical for users who want confidence in sourcing and a straightforward way to increase active folate intake. Many people combine it with methylcobalamin or a B complex for broader methylation support.
Practical limitations
It’s a single‑nutrient approach, so you’ll need to plan additional B‑vitamin support if your goal is comprehensive methylation assistance. If you prefer patented forms like Quatrefolic, check label specifics before purchasing.
Jarrow Formulas 400 mcg Methyl Folate
A reliable 400 mcg dose that works well for maintenance and those who need modest folate support. The brand’s reputation for quality manufacturing makes it a safe option for routine daily use.
Pros
- Trusted brand with strict quality control
- Vegan, gluten‑free, and allergen‑friendly formula
- Gentle daily dose suitable for maintenance
Cons
- Lower 400 mcg dose may be inadequate for therapeutic cases
- Not ideal if you need combined methylation cofactors
Why choose the lower‑dose option
This is a conservative, maintenance‑level methylfolate formulated for people who want regular folate support without high dosing. It’s particularly suitable if you’re starting supplementation or have been advised to take a modest dose.
Product highlights
- 400 mcg methylfolate (5‑MTHF) per veggie capsule
- Free from common allergens and designed for sensitive users
- Clear dosing guidance: one capsule daily for maintenance
Because the dose is lower, you’re less likely to experience overstimulation. The product is a good companion to a multivitamin or targeted B12 supplementation if you need broader support.
Limitations
If you’ve been advised to use therapeutic folate levels (1 mg or higher), this formula may underdeliver. Consider higher-dose or combined products if your clinician recommends it.
Horbäch 1000 mcg Methyl Folate 200 Capsules
Provides 200 quick‑release capsules of 1,000 mcg methylfolate — a cost‑effective option if you plan to use methylfolate daily for months. The large count reduces the hassle of frequent repurchasing and keeps per‑serving cost low.
Pros
- Large 200‑capsule bottle reduces reorder frequency
- Standard 1,000 mcg dose per capsule
- Non‑GMO and gluten‑free labeling
Cons
- No included B12 or additional cofactors
- Bulk bottles may have shorter perceived freshness once opened
Who benefits most
If you’re committed to daily methylfolate and want to minimize shopping, this 200‑capsule bottle delivers a year or longer of supply depending on dose. It’s sensible budgeting for consistent users who pair folate with separate cofactors as needed.
Core attributes
- 1,000 mcg of methylfolate per quick‑release capsule
- 200 capsules per bottle for extended supply
- Marketed as non‑GMO and gluten‑free
It’s a straightforward, single‑ingredient approach that lets you control pairing with B12 or B complex supplements. Many find the capsule easy to swallow and observe steady benefits over time.
Practical notes
Because it lacks cofactors, remember to confirm your B12 status or supplement methylcobalamin alongside this product. Consider storing in a cool, dry place to preserve potency across the large bottle lifespan.
Nutricost 1000 mcg Vegetarian Methylfolate
Provides a straightforward 1,000 mcg methylfolate dose in vegetarian capsules at a competitive price. It’s a no‑frills option for routine supplementation when you want quality without extra cost.
Pros
- Very affordable per serving
- Vegetarian capsules and third‑party testing claims
- No taste, generally easy on the stomach
Cons
- Basic single‑ingredient formula without cofactors
- Less brand recognition than premium clinical brands
Who should consider this
Choose this if you want a dependable 1,000 mcg methylfolate product without spending for premium branding. It’s practical for budget-conscious shoppers who still want effective active folate in a vegetarian capsule.
Features at a glance
- 1,000 mcg methylfolate per capsule
- Vegetarian capsule, non‑GMO, gluten‑free, and made in GMP‑compliant facilities
- Packaged for everyday, long‑term use
You can pair it with a separate methylcobalamin if you want the B12 cofactor included. Users often report easy digestion and consistent effects when used daily.
Practical tips and limitations
As a single‑ingredient product, it won’t cover all B‑vitamin needs for methylation. If you need combined nutrients (riboflavin, B6, betaine), plan to stack or choose a B complex instead.
One Elevated Double Strength Methylfolate Formula
Delivers a double‑strength methylfolate alongside methylcobalamin and other B vitamins designed to work together. It’s tailored to users who want a potent, multi‑cofactor approach to support methylation and neurotransmitter synthesis.
Pros
- High dose methylfolate plus methylcobalamin and B‑vitamins
- Formulated for synergistic methylation support
- Reported benefits for users with MTHFR variants
Cons
- Flavor or aftertaste reported by some users
- May require dose tweaking for optimal results
What it targets
This product aims to be more than a single‑nutrient supplement by pairing double‑strength methylfolate with methylcobalamin and a range of B vitamins (B1, B2, B6, niacin). The idea is to supply cofactors that participate in methylation and neurotransmitter production so you don’t need to stack multiple products.
Notable elements
- Double‑strength methylfolate designed for higher support needs
- Methylcobalamin and other B vitamins included for synergy
- Lab‑tested claims and formulation intended for bioavailability
If you’ve been experimenting with dose and found that single ingredients didn’t move the needle, a combined higher‑strength formula can simplify your routine. Users often report improved energy and mood once they find the right personal dose.
Considerations and cautions
Because it’s multi‑ingredient and potent, you may need to adjust dose or frequency to avoid overstimulation. If you take other B supplements, tally total daily intake to remain within safe ranges.
Final Thoughts on the Best Methylfolate Supplements
For most people looking for a reliable, clinician‑backed daily option, choose Thorne 5‑MTHF Active Methylfolate 1 mg. Strengths: top manufacturing standards, broad clinical use, and a safe, well‑tolerated 1 mg dose that works well as a maintenance or starter regimen. Use it daily for steady support when you want a trusted brand recommended by practitioners.
If you need stronger methylation support or you’ve been advised to use higher folate doses, pick High‑Potency L‑Methylfolate Plus B12 (15 mg). Strengths: very high 5‑MTHF dose plus methylcobalamin for synergy — ideal when clinicians recommend aggressive support for documented needs. Take this option under medical supervision and monitor symptoms as you adjust dose.
What Is Methylfolate and What Is It For?
Methylfolate is the active form of folic acid (vitamin B9). It plays a vital role in fetal development, nervous system health, cardiovascular support, and overall cellular growth. Because it is already in its biologically active form, methylfolate is easier for the body to absorb and utilize compared to synthetic folic acid.
Foods naturally rich in methylfolate include dark leafy greens, whole grains, red meat, dairy products, and eggs. However, supplementation is often recommended to ensure adequate levels, especially for certain groups such as pregnant individuals or those planning pregnancy.
Methylfolate vs. Folic Acid: What’s the Difference?
Folic acid and methylfolate are both forms of vitamin B9, but they are not identical. Folic acid is the synthetic version found in fortified foods and supplements, while methylfolate (5-MTHF or L-methylfolate calcium) is the active form that the body can use directly.
To become active, folic acid must be converted into methylfolate through enzyme activity. Some people, due to genetic variations, have difficulty converting folic acid efficiently. In these cases, using methylfolate supplements can help ensure optimal vitamin B9 activity and better overall results.
Before starting supplementation, consult a healthcare professional to determine your individual needs and the best dosage for your body.
How to Choose the Best Methylfolate Supplements
Choosing the best methylfolate supplements depends on your health goals, dosage requirements, dietary restrictions, and treatment duration. Here’s a breakdown to help you find the ideal option.
1. Select the Right Methylfolate Formula for Your Needs
Different health goals require different dosages and formulations of methylfolate. Below are the main recommendations for specific situations.
For Pregnancy or Those Trying to Conceive: 400–800 mcg Formulas
Methylfolate is essential during early pregnancy for proper fetal neural tube formation and cellular differentiation. Supplementation may reduce the risk of birth defects and support postpartum recovery.
- Dosage: 400–800 mcg per day (800 mcg is commonly recommended during pregnancy).
- Composition: Pure methylfolate without additional ingredients.
- Duration: During pregnancy and up to 6 months postpartum.
Adequate B9 intake can also help reduce the risk of postpartum mood changes and support overall maternal health.
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For General Health or Hair Pigmentation Support: 400 mcg Formulas
Methylfolate may help minimize oxidative stress, which contributes to cellular aging and inflammation. It’s also linked to scalp health and follicle regeneration, making it a potential ally in maintaining hair pigmentation.
- Dosage: 400 mcg per day for general health.
- Composition: Look for formulas containing antioxidants such as CoQ10, zinc, silicon, and vitamins C and E. For anti-inflammatory support, consider options with turmeric, omega-3, or probiotics.
- Duration: Use for at least 3 months for visible results.
Note that genetic factors can also affect hair pigmentation, and supplementation alone may not completely prevent graying.
For Neurological Health Support: Up to 2 mg with B-Vitamin Complex
Methylfolate supports neurotransmitter production, including dopamine and serotonin, which are crucial for mood and cognitive health. It is often used as part of broader treatment plans for conditions related to mental and neurological well-being.
- Dosage: Up to 2 mg (2000 mcg) per day, depending on individual needs.
- Composition: Combine with vitamins B3, B6, and B12 for synergistic brain and mood support.
- Duration: Treatment may last up to 12 months or more, as recommended by a healthcare professional.
Always seek medical guidance before taking high-dose methylfolate, as excess intake can cause unwanted side effects.
2. Look for the Best Value for Money
Methylfolate supplements can vary in price. A good way to find cost-effective options is to calculate the cost per serving. Larger bottles—typically with 60 capsules or more—often offer better value.
For example, if a bottle costs $30 and contains 60 capsules, each dose costs about $0.50. This simple calculation helps compare products more effectively and find the best deal for your needs.
Always check the product’s expiration date, especially when purchasing larger quantities to last several months.
3. For Vegans: Choose Methylfolate with a Certified Vegan Label
If you follow a vegan lifestyle, always verify that your methylfolate supplement carries a certified vegan label. Many capsules are made with gelatin derived from animal sources, and some formulations may include trace ingredients from fish or other animal derivatives.
Look for products clearly labeled as “Vegan” or “Plant-Based” to ensure they are completely free of animal-derived components. Vegan methylfolate options are less common but equally effective as those from animal sources.
Methylfolate is a crucial nutrient for many bodily functions, from fetal development to mental health and cardiovascular balance. When choosing among the best methylfolate supplements, always consider your personal health goals, dietary preferences, and the appropriate dosage.
For optimal safety and effectiveness, it’s best to consult a healthcare professional before beginning any supplementation routine.
Check Out the Best Methylfolate Supplements
Still not sure which one to choose? Click the link below to see the best-selling products.
Also Check Out Other Helpful Articles
Take a look at more useful articles that can help you make more informed decisions.
- Best Omega-3 Supplements for Kids in 2025 (Top 10: Nordic Naturals, MaryRuth and More)
- Best Methylfolate Supplements in 2025 (Top 10: Codeage, Jarrow Formulas and More)
- Best MCT Supplements in 2025 (Top 10: Garden of Life, Nature’s Way and More)
Video About the Best Methylfolate Supplements
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About the Author
Sara Taylor has always loved storytelling. With a natural curiosity, she brings fresh perspectives to every article she works on.